Successful bronchial revascularization in experimental single lung transplantation
| Autor: | J. W. Hoffmann, A. Zonta, Berti A, S. Nazari, F. Moncalvo, Prati U |
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| Rok vydání: | 1990 |
| Předmět: |
Graft Rejection
Pulmonary and Respiratory Medicine medicine.medical_specialty Swine medicine.medical_treatment Aorta Thoracic Bronchi Bronchial Arteries Anastomosis Revascularization Surgical anastomosis medicine.artery medicine Animals Lung business.industry Anastomosis Surgical Respiratory disease General Medicine respiratory system medicine.disease respiratory tract diseases Surgery medicine.anatomical_structure Descending aorta Cardiology and Cardiovascular Medicine Bronchial artery business Lung Transplantation Allotransplantation |
| Zdroj: | European Journal of Cardio-Thoracic Surgery. 4:561-567 |
| ISSN: | 1010-7940 |
| Popis: | It is the purpose of this paper to report our experience with bronchial artery revascularization in an experimental model of single lung transplantation in swine. Thirty-three large white pigs weighing 20-40 kg underwent left lung allotransplantation. In 24 animals, bronchial artery revascularization was attempted by anastomizing the aortic patch containing the bronchial artery orifice with the recipient descending aorta. Eight survivors were put to death on postoperative days 11-15; five animals were put to death or died on postoperative days 2-9; the other animals died intra-operatively or within a few hours. Preservation of left bronchial vascularization was achieved in all cases attempted, as documented by post-mortem injection of dye (methylene blue) or contrast medium. Five of the 8 animals surviving for 11-15 days showed diffuse graft hepatization, associated with diffuse vascular thrombosis. Whether this was caused by damage to the endothelium due to poor graft preservation or by rejection was unclear. In animals surviving for 11-15 days without gross lung pathology, the anastomosis and bronchial mucosa were completely normal; in contrast, bronchial ischaemic changes were found in nonrevascularized animals and in survivors with graft hepatization. Our experience confirms that re-anastomosis of the bronchial arteries can prevent bronchial healing problems in single lung transplantation. The pig is an ideal model for these experiments since the bronchial arteries have a constant common aortic origin, allowing easy identification and preservation of left bronchial vascularization. |
| Databáze: | OpenAIRE |
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