The Risk of QTc Prolongation in Non-Diabetic and Diabetic Patients Taking Tyrosine Kinase Inhibitors (TKIs)- A Patient Safety Project at a Private Oncology Practice
| Autor: | Ying Luu, Imran Husain, Peng Yang, David Chu, Alan Kaell, Ira L. Cohen, Zhongju Lu, Jack Ip, Michael Lu, Chang-Kyung Kim, Richard Z. Lin |
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| Rok vydání: | 2021 |
| Předmět: |
QTC PROLONGATION
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Disease QT interval cancer treatment tyrosine kinase inhibitors (TKIS) Internal medicine Diabetes mellitus Internal Medicine Medicine cardiovascular diseases diabetes business.industry medicine.disease RC31-1245 respiratory tract diseases Risk evaluation Increased risk cardiovascular system torsade’s de pointes (TDP) QTc prolongation business After treatment Research Article circulatory and respiratory physiology Non diabetic |
| Zdroj: | Journal of Community Hospital Internal Medicine Perspectives article-version (VoR) Version of Record Journal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 6, Pp 799-807 (2021) |
| ISSN: | 2000-9666 |
| Popis: | Objective: To assess the prevalence of QTc prolongation in both non-diabetic and diabetic patients on TKIs. Some TKIs have been reported to cause QTc prolongation, which is prevalent in diabetes. However, there is no Risk Evaluation and Mitigation Strategy using series ECG to monitor those patients. Methods: Patients taking TKIs, with two ECGs recorded between 1 January 2010 and 31 December 2017 were selected from the electronic database. The QTc duration >450 ms was determined as prolonged. Percentage of QTc prolongation on participants were compared using Chi-Square test. Results: This study included 313 patients (age 66.1 ± 0.8 years and 57.5% are female) taking TKIs. In non-Diabetic patients, the prevalence of QTc prolongation is 19.1% (n = 253) before and 34.8% (n = 253) after treatment with TKIs (p |
| Databáze: | OpenAIRE |
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