Role of Interleukin-17 in Acute Pancreatitis
| Autor: | Le Li, Li-Wei Liu, Peng Xiao, Bei Sun, Yang Zhang, Hongtao Tan, Guanqun Li, Xinglong Geng, Yu Xie, Hongze Chen, Tao Zhang, Tianqi Lu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Poor prognosis
T helper 17 cells acute pancreatitis medicine.medical_treatment Immunology gut microbiome Review immune response Pathogenesis Mice Immune system Risk Factors medicine Immunology and Allergy Animals Humans Clinical significance Molecular Targeted Therapy Cause of death business.industry Interleukin-17 Immunity RC581-607 medicine.disease Gastrointestinal Microbiome Disease Models Animal Cytokine Treatment Outcome Pancreatitis Acute pancreatitis Th17 Cells Interleukin 17 Immunologic diseases. Allergy business |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
| ISSN: | 1664-3224 |
| Popis: | Acute pancreatitis (AP) is a leading cause of death and is commonly accompanied by systemic manifestations that are generally associated with a poor prognosis. Many cytokines contribute to pancreatic tissue damage and cause systemic injury. Interleukin-17 (IL-17) is a cytokine that may play a vital role in AP. Specifically, IL-17 has important effects on the immune response and causes interactions between different inflammatory mediators in the AP-related microenvironment. In this literature review, we will discuss the existing academic understanding of IL-17 and the impacts of IL-17 in different cells (especially in acinar cells and immune system cells) in AP pathogenesis. The clinical significance and potential mechanisms of IL-17 on AP deterioration are emphasized. The evidence suggests that inhibiting the IL-17 cytokine family could alleviate the pathogenic process of AP, and we highlight therapeutic strategies that directly or indirectly target IL-17 cytokines in acute pancreatitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|