Configuration and conformation of the A-ring of 1-methyl steroids

Autor:	F.A. MacKellar, Rudolf Wiechert, G. Slomp, U. Kerb, W.J. Wechter
Rok vydání:	1965
Předmět:	Chemistry Magnetic Resonance Spectroscopy Chemical Phenomena Hydrocortisone Models Chemical Stereochemistry Organic Chemistry Drug Discovery Steroids Ring (chemistry) Biochemistry
Zdroj:	Tetrahedron. 21:1625-1634
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(01)98325-5
Popis:	A detailed NMR analysis of epimeric pairs of 1-methylated steroids in the A/B cis and Δ4-series has confirmed earlier configurational assignments. One-methyl steroids in the A/B trans series and the 1-methyl hydrocortisone synthesized therefrom are revised from the α to β-configuration. One-β-methyl-5α and 1β-methyl-Δ4 steroids were judged to be distorted from the normal chair-formed A-ring conformation, the former into the twist and the latter into the alternative half-chair form.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b75a324ea5916ca997ce4281efc475 https://doi.org/10.1016/s0040-4020(01)98325-5 Zobrazit plný text záznamu