No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants
| Autor: | Shuo Fang, Die Fan, Qiangsheng He, Wenbo Meng, Yulong He, Changhua Zhang, Jinqiu Yuan, Huachun Zou, Man Yang, Xiwen Qin, Junjie Huang, Zi-Chong Kuo, Yihang Pan, Bin Xia |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Hepatology business.industry Proportional hazards model Confounding Gastroenterology Cause specific mortality Proton Pump Inhibitors Middle Aged Brief Communication Risk Assessment Cohort Studies Prospective analysis Population based cohort Increased risk Internal medicine Cause of Death Medicine Humans Female Prospective Studies business All cause mortality Aged |
| Zdroj: | The American Journal of Gastroenterology |
| ISSN: | 1572-0241 0002-9270 |
| Popis: | Introduction The association between proton pump inhibitors' (PPIs) use and mortality remains unclear. Methods This was a prospective analysis of 440,840 UK residents and 13,154 deaths. We evaluated the associations with multivariate Cox regression. Results After adjusting for confounders, such as over health status and longstanding diseases, the regular use of PPIs was not associated with an increased risk of all-cause mortality and mortality due to neoplasms, circulatory system diseases, respiratory system diseases, digestive system diseases, external causes, and other causes. Discussion Regular use of PPIs was not associated with an increased risk of all-cause and cause-specific mortality. |
| Databáze: | OpenAIRE |
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