No Evidence for Spread of Plasmodium falciparum Artemisinin Resistance to Savannakhet Province, Southern Laos

Autor: Maniphone Khanthavong, Bongkot Soonthornsata, Nicholas J. White, Bouasy Hongvanthong, Odai Chanthongthip, Sue J. Lee, Samlane Phompida, Kasia Stepniewska, Pascal Ringwald, Tiengkham Pongvongsa, Mallika Imwong, Paul N. Newton, Mayfong Mayxay
Rok vydání: 2012
Předmět:
Male
Drug Resistance
Administration
Oral
Artesunate
Parasitemia
Drug resistance
law.invention
chemistry.chemical_compound
0302 clinical medicine
Dihydroartemisinin/piperaquine
Randomized controlled trial
law
030212 general & internal medicine
Artemether
Malaria
Falciparum
Child
biology
Articles
Middle Aged
Artemisinins
3. Good health
Drug Combinations
Treatment Outcome
Infectious Diseases
Ethanolamines
Laos
Drug Therapy
Combination
Female
medicine.drug
Adult
medicine.medical_specialty
Adolescent
Plasmodium falciparum
030231 tropical medicine
Antimalarials
Young Adult
03 medical and health sciences
Virology
Internal medicine
parasitic diseases
medicine
Humans
Aged
Fluorenes
business.industry
Artemether
Lumefantrine Drug Combination
medicine.disease
biology.organism_classification
Surgery
chemistry
Parasitology
business
Malaria
Follow-Up Studies
Zdroj: The American Journal of Tropical Medicine and Hygiene
ISSN: 1476-1645
0002-9637
DOI: 10.4269/ajtmh.2012.11-0497
Popis: We conducted an open-label, randomized clinical trial to assess parasite clearance times (PCT) and the efficacy of 4 mg/kg (group 1, n = 22) and 2 mg/kg (group 2, n = 22) of oral artesunate for three days followed by artemether-lumefantrine in patients with uncomplicated Plasmodium falciparum malaria at Xepon Interdistrict Hospital, Savannakhet Province in southern Laos. Slides were read in duplicate. The overall mean (95% confidence interval; range) PCT in hours was 23.2 (21.2-25.3; 12-46) and 22.4 (20.3-24.5; 12-46) for the first and second microscopists, respectively (P = 0.57). Ten (23%) patients remained parasitemic on day 1 after treatment (4 [18%] in group 1 and 6 [27%] in group 2; P = 0.47). No patient had patent asexual parasitemia on the second and third days of treatment. The 42-day polymerase chain reaction-corrected cure rates were 100% in both treatment groups. Serious adverse events did not develop during or after treatment in any patients. In conclusion, no evidence of P. falciparum in vivo resistance to artesunate was found in southern Laos.
Databáze: OpenAIRE
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