| Autor: |
Juan-Li Duan, Zi-Yi Zhou, Bai Ruan, Zhi-Qiang Fang, Jian Ding, Jing-Jing Liu, Ping Song, Hao Xu, Chen Xu, Zhen-Sheng Yue, Hua Han, Guo-Rui Dou, Lin Wang |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Cellular and molecular gastroenterology and hepatology. 13(6) |
| ISSN: |
2352-345X |
| Popis: |
Liver sinusoidal endothelial cells (SECs) promote the proliferation of hepatocytes during liver regeneration. However, the specific subset of SECs and its mechanisms during the process remain unclear. In this study, we investigated the potential role of c-kitPartial hepatectomy mice models were established to induce liver regeneration. Hepatic c-kit expression was detected by quantitative reverse-transcription polymerase chain reaction, immunofluorescent staining, and fluorescence-activated cell sorting. VE-cadherin-cyclization recombinase-estrogen receptor (Cdh5-Cre-ERT) Notch intracellular domain and Cdh5-Cre recombination signal binding protein JκHepatic c-kit is expressed predominantly in SECs. Liver resident SECs contribute to the increase of c-kit during partial hepatectomy-induced liver regeneration. Isolated c-kitOur results suggest that c-kit |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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