In vitro antimicrobial activity of ZnO based glass-ceramics against pathogenic bacteria
| Autor: | Farhat Saleemi, Madeeha Riaz, Rehana Zia, Hafeez Ikram, Farooq Bashir |
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| Rok vydání: | 2015 |
| Předmět: |
Ceramics
Materials science Biomedical Engineering Biophysics chemistry.chemical_element Bioengineering Zinc In Vitro Techniques medicine.disease_cause Bacterial cell structure Microbiology Biomaterials medicine Agar diffusion test Dissolution biology Bacteria Calorimetry Differential Scanning Pathogenic bacteria biology.organism_classification Antimicrobial Anti-Bacterial Agents chemistry Solubility Glass Zinc Oxide Antibacterial activity Powder Diffraction Nuclear chemistry |
| Zdroj: | Journal of materials science. Materials in medicine. 26(12) |
| ISSN: | 1573-4838 |
| Popis: | The antibacterial activity of ZnO (0-15.53 mol%) based SiO2-CaO-P2O5-Na2O-CaF2 bioactive glass-ceramics synthesized by controlled crystallisation were studied against eight micro-organisms using modified Kirby Bauer method. The antibacterial activity of the specimens was statistically evaluated using one-way analysis of variance and P < 0.05 was used as the level of significance. In vitro dissolution tests were performed in stimulated body fluid for 48 h at 37 °C for different time intervals to correlate the dissolution behaviour of test samples with antibacterial effects. The results illustrate that specimen BZn15.53 having the highest concentration of ZnO (15.53 mol%) demonstrated the strongest effect against Staph.aureus, S. epidermidis, B. subtilis and K. pneumonia. The effectiveness of BZn15.53 in inhibiting bacteria was due to accumulation of Zn(+2) ions around the surface of the bacteria cell release that caused the death of the cell, besides the presence of hydroxyapatite phase was also responsible for damaging the cell membrane of bacteria. |
| Databáze: | OpenAIRE |
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