Pharmacological evaluation of Apium leptophyllum (Pers.) on bronchial asthma
| Autor: | Ganesh Patro, Himanshu Bhusan Sahoo, D. Priyadarshini, Saroj Kumar Sahoo, Madhulita Panda, Rakesh Sagar |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Contraction (grammar) Short Communication lcsh:Analytical chemistry lcsh:RS1-441 Bioengineering Pharmacology 030226 pharmacology & pharmacy General Biochemistry Genetics and Molecular Biology Bronchospasm lcsh:Pharmacy and materia medica Guinea pig 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine General Pharmacology Toxicology and Pharmaceutics Apium leptophyllum Asthma lcsh:QD71-142 business.industry Degranulation asthma medicine.disease Mast cell histamine mast cell degranulation 030104 developmental biology medicine.anatomical_structure chemistry bronchospasm Immunology medicine.symptom business Acetylcholine Histamine medicine.drug |
| Zdroj: | Journal of Pharmacy and Bioallied Sciences, Vol 8, Iss 4, Pp 341-345 (2016) Journal of Pharmacy & Bioallied Sciences |
| ISSN: | 0975-7406 |
| DOI: | 10.4103/0975-7406.199343 |
| Popis: | Objective: The present study was to investigate the antiasthmatic potential from the flavonoid fraction of Apium leptophyllum fruit (FFALF) to validate its traditional claim. Materials and Methods: The antiasthmatic activity of FFALF was evaluated by histamine or acetylcholine-induced bronchospasm model in guinea pigs, compound 48/80 induced mast cell degranulation in albino rats and histamine-induced tracheal contraction in guinea pig. The preconvulsion dyspnea time at 0th and 7th day at the dose of 100 and 200 mg/kg in guinea pig's bronchospasm model, the percentage of granulated and degranulated mast cell at the dose of 500, 750, and 1000 μg/ml in rats and tracheal contraction at the dose of 500, 750, and 1000 μg/ml in guinea pig were measured and compared with respective control groups. Results: The treatments of FFALF were significantly (P < 0.001) decreased the histamine/acetylcholine-induced bronchospasm, mast cell degranulation, and histamine-induced tracheal contraction as compared to inducer group. In addition, FFALF showed dose-dependent antiasthmatic activity in all the animals. Conclusion: Hence, this study suggested that the FFALF showed antiasthmatic activity probably by membrane stabilizing property as well as suppressing antibody production and inhibiting of antigen induced by histamine and acetylcholine. |
| Databáze: | OpenAIRE |
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