Heart rate and microinflammation in men: a relevant atherothrombotic link
| Autor: | Itzhak Shapira, Ori Rogowski, Samuel Melamed, Sharon Toker, Arie Shirom, Shlomo Berliner |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Neutrophils Coronary Artery Disease Fibrinogen Body Mass Index Leukocyte Count Heart Rate Risk Factors Internal medicine Heart rate medicine Humans Exercise Inflammation biology medicine.diagnostic_test business.industry Vascular disease C-reactive protein Age Factors Thrombosis Middle Aged medicine.disease Atherosclerosis Lipids Endocrinology C-Reactive Protein Cohort biology.protein Cardiology Linear Models Cardiology and Cardiovascular Medicine business Lipid profile Body mass index Biomarkers medicine.drug |
| Zdroj: | Heart (British Cardiac Society). 93(8) |
| ISSN: | 1468-201X |
| Popis: | To explore the possibility that increased resting heart rate (HR) is associated with a microinflammatory response. Such an association could explain, at least in part, the recently described worse cardiovascular prognosis in individuals with increased HR.Concentrations of fibrinogen and high-sensitivity C-reactive protein, as well as the absolute number of polymorphonuclear leucocytes, were analysed in a cohort of 4553 apparently healthy men and in those with atherothrombotic risk factors.Following adjustment for age and body mass index, lipid profile and cardiovascular risk factors, a significant (p0.001) difference was noted between individuals in the first quintile of HR (or =58 beats/min) and those in the fifth quintile (or =79 beats/min) regarding all the above-mentioned inflammatory biomarkers, the respective mean values being 7.38 and 8.11 micromol/l, 1.12 and 1.61 mg/l, and 4.23 and 4.74 x 10(9)/l.Resting HR is associated with a microinflammatory response in apparently healthy men and in those with atherothrombotic risk factors. Sympathetic activation might be a common factor explaining such an association. If confirmed in additional studies, this association might be a relevant target for therapeutic manipulations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|