Palladium‐Catalyzed Cascade Cyclization/Alkylation of Oxime Ethers: Assembly of 4‐Alkylisoxazoles by 'Chain‐Walking' Strategy

Autor:	Yin‐Long Lai, Shao‐Xi Yan, Sheng‐Ling Zhang, Yu‐Hong Huang, Ru‐Xin Hu, Yang‐Chong Chen, Jian‐Min Luo, Jianxiao Li
Rok vydání:	2022
Předmět:	Molecular Structure Alkylation Cyclization Oximes Organic Chemistry General Chemistry Alkenes Biochemistry Palladium Catalysis Ethers
Zdroj:	Chemistry – An Asian Journal. 17
ISSN:	1861-471X 1861-4728
Popis:	A reliable and efficient palladium-catalyzed cascade cyclization/alkylation of oxime ethers with unactivated alkenes is described, affording a whole variety of structurally diverse isoxazole derivatives in moderate to good yields with excellent functional group compatibility. Ionic liquid [Aeim]Br not only acts as an environmentally friendly solvent but also acts as an accelerating agent to provide excess bromine source to eliminate bromomethane from oxime ethers. More importantly, the use of "chain-walking" strategy provides a novel methodology in organic synthesis to rapid generation of molecular complexity from readily available starting materials.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58afe799d3f85349f706bc1ca79cc2d7 https://doi.org/10.1002/asia.202200806 Zobrazit plný text záznamu Plný text