Use of 'locked-in' antibiotic to treat an unusual gram-negative hemodialysis catheter infection
| Autor: | Donald A. Feinfeld, Jirgis Shah |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Stenotrophomonas maltophilia Antibiotics Vascular access Ceftazidime Catheters Indwelling Antiphospholipid syndrome Renal Dialysis medicine Humans cardiovascular diseases business.industry Hemodialysis Catheter Infection Maintenance hemodialysis medicine.disease Surgery Cephalosporins Catheter Injections Intravenous Kidney Failure Chronic Female Hemodialysis business Complication Gram-Negative Bacterial Infections |
| Zdroj: | Nephron. 85(4) |
| ISSN: | 1660-8151 |
| Popis: | A 37-year-old woman on maintenance hemodialysis for 3 years had multiple vascular access failures due to antiphospholipid syndrome. She was dialyzed via a tunneled left subclavian catheter, but after 1 year developed chills and fever during each dialysis session. Blood cultures grew out Xanthomonas maltophilia sensitive to ceftazidime and ciprofloxacin. Intravenous administration of both antibiotics failed to eradicate infection. We added ‘locked-in’ ceftazidime, instilling it daily into the catheter along with heparinized saline for 3 weeks. Within 24 h the patient was dialyzed uneventfully, and all subsequent blood cultures have been negative. This case shows the successful use of a ‘locked-in’ antibiotic to treat an unusual gram-negative catheter infection. Two prior series have reported similar good results in infections with more common organisms. Such treatment may permit continued use of tunneled hemodialysis catheters for longer periods. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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