Involvement of two or more sets of lacrimal glands and/or major salivary glands is related to greater systemic disease activity due to multi-organ involvement in IgG4-related dacryoadenitis/sialadenitis
| Autor: | Kazuyuki Suzuki, Kiyoaki Ito, Hiroshi Fujii, Satoshi Hara, Hiroyuki Kawahara, Akari Takeji, Mitsuhiro Kawano, Ichiro Mizushima, Yoshinori Takahashi, Hajime Sanada, Masahiro Konishi |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Systemic disease Pathology medicine.medical_specialty Salivary Glands Sialadenitis Disease activity 03 medical and health sciences Dacryocystitis 0302 clinical medicine Rheumatology Major Salivary Gland Medicine Humans 030212 general & internal medicine Aged Retrospective Studies 030203 arthritis & rheumatology business.industry Dacryoadenitis Lacrimal Apparatus medicine.disease Multi-organ involvement Immunoglobulin G IgG4-related disease Female business |
| Zdroj: | Modern rheumatology. 31(6) |
| ISSN: | 1439-7609 |
| Popis: | Objectives In IgG4-related dacryoadenitis and/or sialadenitis (IgG4-DS), involvement of two or more sets of lacrimal glands (LGs) and/or major salivary glands (MSGs) is regarded as a specific finding with diagnostic significance. This study aimed to clarify the influence of this factor on the overall clinical picture of IgG4-DS. Methods We retrospectively reviewed the medical records of 130 patients with IgG4-related disease, 97 of whom were diagnosed with IgG4-DS. We determined their clinical features according to the presence/absence of involvement of ≥2 sets of LGs and/or MSGs and compared the results with those obtained in 33 DS-limited patients. Results The IgG4-DS patients comprised 60 men and 37 women (median age 65 years). The median serum IgG4 level at diagnosis was 548 mg/dL. The patients with involvement of ≥2 sets (n = 44) had significantly more affected organs, lower serum C3 and C4 levels, and a tendency to have higher serum IgG levels and IgG4-RD responder index than did those without it (n = 53). In the 33 DS-limited patients, these two groups had no significant differences in clinical features. Conclusions Involvement of ≥2 sets of LGs and/or MSGs suggests greater systemic disease activity mainly reflected by involvement of more organs. |
| Databáze: | OpenAIRE |
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