Cystic Cholangioma in the Thoracic Cavity of a Rat
| Autor: | Mami Kouchi, Yoshiko Michimae, Takatoshi Koujitani, Hitoshi Funabashi, Tomoaki Tochitani, Takaki Seki, Kaoru Toyosawa, Kazuo Okimoto, Izumi Matsumoto |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty thoracic Connective tissue Case Report Vimentin Toxicology Pathology and Forensic Medicine Cytokeratin cystic cholangioma medicine rat Mesothelin Esophagus ectopic liver biology Thoracic cavity business.industry diaphragmatic hernia congenital Anatomy Ectopic liver medicine.anatomical_structure biology.protein Immunohistochemistry business |
| Zdroj: | Journal of Toxicologic Pathology |
| ISSN: | 1881-915X 0914-9198 |
| DOI: | 10.1293/tox.25.41 |
| Popis: | A female congenic rat produced by repeated backcrossing of Nihon rats, a model for hereditary renal cell carcinoma, to Brown Norway rats was necropsied at 24 months of age. At necropsy, a white mass about 1 centimeter in size was observed in the thoracic cavity, and the mass partly adhered to the esophagus and the diaphragm. Histologically, the mass was clearly circumscribed by connective tissue, and consisted of neoplastic cuboidal epithelial cells that showed cystic tubular proliferation. Some islands of well-differentiated hepatocytes and some vessels were observed in the mass. Immunohistochemically, the tumor cells were strongly positive for cytokeratin and partly positive for vimentin but were negative for mesothelin and Von Willebrand Factor. The positive rate for Ki-67 was 2.4%. Based on these histological and immunohistochemical evidences, we diagnosed this tumor as a cystic cholangioma that might have arisen from the ectopic hepatic tissue in the thoracic cavity. |
| Databáze: | OpenAIRE |
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