Exploiting ionisable nature of PEtOx-co-PEI to prepare pH sensitive, doxorubicin-loaded micelles

Autor: Umut Ugur Ozkose, Naile Öztürk, Sevgi Gulyuz, Asuman Bozkir, Mehmet Atilla Tasdelen, Ozgur Yilmaz, Asli Kara, Imran Vural
Přispěvatelé: [Belirlenecek]
Rok vydání: 2020
Předmět:
Zdroj: Journal of Microencapsulation. 37:467-480
ISSN: 1464-5246
0265-2048
DOI: 10.1080/02652048.2020.1792566
Popis: Aims This study was conducted to evaluate block copolymers containing two different poly(ethyleneimine) (PEI) amounts, as new pH-sensitive micellar delivery systems for doxorubicin. Methods Micelles were prepared with block copolymers consisting of poly(2-ethyl-2-oxazoline)-co-poly(ethyleneimine) (PEtOx-co-PEI) and poly(epsilon-caprolactone) (PCL) as hydrophilic and hydrophobic blocks, respectively. Doxorubicin loading, micelle size, pH-dependent drug release, and in vitro cytotoxicity on MCF-7 cells were investigated. Results The average size of drug-loaded micelles was under 100 nm and drug loading was between 10.7% and 48.3% (w/w). pH-sensitive drug release was more pronounced (84.7% and 68.9% (w/w) of drug was released at pH 5.0 and pH 7.4, respectively) for the micelles of the copolymer with the lowest PEI amount. The cell viability of doxorubicin-loaded micelles which were prepared by the copolymer with the lowest PEI amount was 28-33% at 72 h. Conclusions PEtOx-co-PEI-b-PCL micelles of this copolymer were found to be stable and effective pH-sensitive nano-sized carriers for doxorubicin delivery. TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [213M728] This study was supported by TUBITAK Grant 213M728. WOS:000547724300001 2-s2.0-85087898563 PubMed: 32627670
Databáze: OpenAIRE
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