IgG Seroprevalence of COVID-19 among Individuals without a History of the Coronavirus Disease Infection in Daegu, Korea
| Autor: | Myung Rae Cho, Jung Suk Do, Suk Kyoon Song, Dae Won Kang, Kyung-Tae Kim, Jun Ho Nam, Sang Gyung Kim, Duk Hee Lee |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Pneumonia Viral Antibodies Viral Ambulatory Care Facilities Polymerase Chain Reaction Undiagnosed Diseases Serology Betacoronavirus Young Adult 03 medical and health sciences 0302 clinical medicine Seroepidemiologic Studies Surveys and Questionnaires Republic of Korea Pandemic medicine Humans Mass Screening Seroprevalence Outpatient clinic Serologic Tests 030212 general & internal medicine Pandemics Mass screening Aged Aged 80 and over SARS-CoV-2 business.industry COVID-19 General Medicine Middle Aged Confidence interval Immunoglobulin G Female Contact Tracing Coronavirus Infections business Contact tracing |
| Zdroj: | Journal of Korean Medical Science. 35 |
| ISSN: | 1598-6357 1011-8934 |
| DOI: | 10.3346/jkms.2020.35.e269 |
| Popis: | Background Seroprevalence studies of coronavirus disease 2019 (COVID-19) from many countries have shown that the number of undiagnosed missing cases is much larger than that of confirmed cases, irrespective of seroprevalence levels. Considering the strategy of Korea entailing massive testing and contact tracing from the beginning of epidemic, the number of undiagnosed missing cases in Korea may be negligible. This study was conducted to estimate the seroprevalence of COVID-19 among individuals who were never diagnosed with COVID-19 in Daegu, the epicenter of COVID-19 epidemic in Korea. Methods Serologic testing for immunoglobulin G antibody based on immunochromatographic assay was conducted in 103 patients and 95 guardians aged 18 to 82 years without any history of COVID-19 diagnosis, who visited outpatient clinics of a single university-affiliated hospital from May 25 to June 5, 2020. Results The estimated seroprevalence was 7.6% (95% confidence interval, 4.3%-12.2%) with 15 positive cases. Among them, only one had a polymerase chain reaction (PCR)-confirmed case among their close contacts and 13 did not experience COVID-19-related symptoms. Seroprevalence was similar between patients and guardians. Based on this figure, the number of undiagnosed missing cases in Daegu was estimated to be a dozen times more than the number of confirmed cases based on PCR testing. Conclusion Despite the limitation of a small and unrepresentative sample, this is the first study on seroprevalence of COVID-19 in Korea. Our study suggested that the number of undiagnosed missing cases was substantial even with the stringent strategy adopted in Korea, similar to that of other countries. |
| Databáze: | OpenAIRE |
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