High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors
| Autor: | L Beltz, G Mazzara, Alison J. Logar, Charles R. Rinaldo, Xiao Li Huang, Ming Ding, M Cottrill, J Liebmann, D Panicali, Zheng Fan |
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| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Immunology Human immunodeficiency virus (HIV) HIV Infections Disease Biology CD8-Positive T-Lymphocytes medicine.disease_cause Microbiology Peripheral blood mononuclear cell chemistry.chemical_compound Virology HIV Seropositivity medicine Cytotoxic T cell Humans Aged Acquired Immunodeficiency Syndrome RNA virus diseases Middle Aged chemistry Insect Science DNA Viral HIV-1 RNA Viral Viral load Immunologic Memory CD8 DNA Research Article T-Lymphocytes Cytotoxic |
| Popis: | Lack of disease in long-term nonprogressors with human immunodeficiency virus type 1 (HIV-1) infection was strongly associated with very low copy numbers of HIV-1 DNA and RNA in peripheral blood mononuclear cells and plasma and the presence of high levels of anti-HIV-1 CD8+ memory cytotoxic T lymphocytes specific for Gag, Pol, and Env, compared with levels present in intermediate and advanced progressors. CD8+ memory cytotoxic T lymphocytes may have an important role in controlling HIV-1 replication and preventing disease in long-term nonprogressors. |
| Databáze: | OpenAIRE |
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