The entorhinal cortex plays a role in extinction
| Autor: | Martín Cammarota, Janine I. Rossato, Juliana Sartori Bonini, Luciana A. Izquierdo, Ivan Izquierdo, Lia R. M. Bevilaqua |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Cognitive Neuroscience Conditioning Classical Central nervous system Experimental and Cognitive Psychology Inhibitory postsynaptic potential Extinction Psychological Behavioral Neuroscience chemistry.chemical_compound Ca2+/calmodulin-dependent protein kinase Avoidance Learning medicine Animals Entorhinal Cortex Rats Wistar Anisomycin Brain Mapping Memoria Fear Extinction (psychology) Amygdala Entorhinal cortex Rats Inhibition Psychological medicine.anatomical_structure chemistry Calcium-Calmodulin-Dependent Protein Kinases Mental Recall NMDA receptor Calcium-Calmodulin-Dependent Protein Kinase Type 2 Psychology Neuroscience |
| Zdroj: | Neurobiology of Learning and Memory. 85:192-197 |
| ISSN: | 1074-7427 |
| DOI: | 10.1016/j.nlm.2005.10.001 |
| Popis: | In this study, we analyzed the participation of the entorhinal cortex in extinction of a learned aversive response. Rats with infusion cannulae aimed to the entorhinal cortex were trained in a one-trial step-down inhibitory avoidance task (IA) and submitted to four consecutive daily test sessions without the footshock, a procedure that induced extinction of the conditioned response in control animals. When infused into the entorhinal cortex immediately after the first extinction session at doses able to block consolidation of IA memory, the NMDA receptor antagonist, AP5 (25 nmol/side), the inhibitor of protein synthesis anisomycin (300 nmol/side) and the inhibitor of CaMKII, KN-93 (10 nmol/side), but not the MEK1/2 inhibitor PD-98059 (5 nmol/side) hindered extinction of the IA response. The same results were obtained when the interval between the first and second test session was 48 instead of 24 h. The data indicate that normal functionality of the NMDA receptors, together with CaMKII activity and protein synthesis are necessary in the entorhinal cortex at the time of the first test session to generate extinction. Our results also suggest that the ERK1/2 pathway does not play a role in this process. |
| Databáze: | OpenAIRE |
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