The relationship between Vitamin D status and exacerbation in COPD patients– a literature review
| Autor: | Laura Caram, Irma Godoy, Suzana Erico Tanni, Sergio A. R. Paiva, Renata Ferrari |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Vitamin medicine.medical_specialty Exacerbation Vitamin D-binding protein Population Pulmonary Disease Chronic Obstructive 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Meta-Analysis as Topic Polymorphism (computer science) Internal medicine medicine Vitamin D and neurology Humans 030212 general & internal medicine Vitamin D education Clinical Trials as Topic education.field_of_study Polymorphism Genetic business.industry Vitamin D-Binding Protein Vitamin D Deficiency Clinical trial Observational Studies as Topic 030228 respiratory system chemistry Female Observational study business |
| Zdroj: | Respiratory Medicine. 139:34-38 |
| ISSN: | 0954-6111 |
| DOI: | 10.1016/j.rmed.2018.04.012 |
| Popis: | Objective To investigate the relationship between Vitamin D and exacerbation in COPD patients. Methods The PubMed database was searched for articles published from 2012 onwards using search terms related to Vitamin D and exacerbation in COPD patients. Meta-analysis, clinical trials, observational studies, and human studies were included. Non-English articles or articles with full text unavailable were excluded; a total of 15 articles were selected. Results The association between exacerbation frequency and Vitamin D levels in observational studies remains controversial, however, meta-analysis revealed a negative association between serum Vitamin D and exacerbation. Also, two clinical trials showed that Vitamin D3 supplementation in COPD patients reduced the risk of moderate and severe exacerbation. Vitamin D binding protein (VDBP) polymorphisms seem to affect patient exacerbation susceptibility. Conclusions Few studies in literature have data related to diet, 25-hydroxyVitamin D [25(OH)D] and polymorphism in COPD exacerbation. One clinical trial indicates Vitamin D supplementation plays a role in COPD patients with hypovitaminosis D in preventing exacerbations. Further studies are needed to elucidate the role of Vitamin D in this population and to establish the best marker for Vitamin D, which patient subgroups will benefit, and the best supplement dosage without leading to toxicity. |
| Databáze: | OpenAIRE |
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