Detection of Repolarization Alternans With an Implantable Cardioverter Defibrillator Lead in a Porcine Model
| Autor: | David J. Christini, Anil Maybhate, Bruce B. Lerman, Steven Hao, Kenneth M. Stein, Sei Iwai, Amit B Guttigoli, Jae Ung Lee |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Swine medicine.medical_treatment Biomedical Engineering Ventricular tachycardia Sensitivity and Specificity Internal medicine Occlusion Animals Medicine Repolarization Diagnosis Computer-Assisted Fibrillation medicine.diagnostic_test business.industry Balloon catheter Reproducibility of Results Implantable cardioverter-defibrillator medicine.disease Defibrillators Implantable Electrodes Implanted Ventricular fibrillation Electrocardiography Ambulatory Tachycardia Ventricular Cardiology medicine.symptom business Electrocardiography Algorithms |
| Zdroj: | IEEE Transactions on Biomedical Engineering. 52:1188-1194 |
| ISSN: | 0018-9294 |
| Popis: | Mechanistic links have been suggested between repolarization alternans (RPA) and the onset of ventricular tachycardia (VT) and/or fibrillation. Endocardial detection of RPA may, therefore, be an important step in future device-based treatments of arrhythmias. Here, we investigate if RPA could be detected during acute ischemia using an implantable cardioverter defibrillator (ICD) lead (tip to distal coil) located in the right ventricular apex. In 18 pigs, the right coronary (n=10) or left anterior descending coronary (n=8) artery was occluded for 10 min using a balloon catheter, followed by reperfusion for 30 min, and re-occlusion for 30 min. RPA magnitude, computed using the modified moving average (MMA) method, showed a sharp increase in all 18 animals, from a mean baseline level of 1.9/spl plusmn/1.3 mV to 3.0/spl plusmn/1.3 mV during first occlusion (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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