Allergy to bumblebee venom. II IgE cross-reactivity between bumblebee and honeybee venom
| Autor: | H. de Groot, S. O. Stapel, J. Waanders‐Lijster de Raadt, A.W. van Toorenenbergen |
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| Rok vydání: | 2008 |
| Předmět: |
Hypersensitivity
Immediate Blotting Western Immunology Zoology Venom Hymenoptera Cross Reactions Immunoglobulin E medicine.disease_cause Cross-reactivity Epitopes Radioallergosorbent Test Botany medicine Animals Humans Immunology and Allergy Bumblebee biology Apidae biology.organism_classification Europe Bee Venoms Aculeata Bombus terrestris North America biology.protein Electrophoresis Polyacrylamide Gel |
| Zdroj: | Allergy. 53:769-777 |
| ISSN: | 0105-4538 |
| DOI: | 10.1111/j.1398-9995.1998.tb03973.x |
| Popis: | To obtain more information on IgE cross-reactivity between bumblebee venom and honeybee venom, we tested sera from venom-sensitized patients for specific IgE against venoms from the European bumblebee (Bombus terrestris), the North American bumblebee (Megabombus pennsylvanicus), and the honeybee (Apis mellifera). RAST, RAST-inhibition, and immunoblotting experiments indicate that bumblebee venom and honeybee venom contain venom-specific IgE-binding epitopes. These results suggest that immunotherapy using honeybee venom may not be effective in all bumblebee venom-allergic patients. Our experiments also revealed differences in IgE binding for venom from European and American bumblebees. |
| Databáze: | OpenAIRE |
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