Changes in serum levels of Apo AIV in patients with newly diagnosed hyperthyroidism and hypothyroidism: a preliminary study
Autor: | Alireza Ansari-Moghaddam, Avadan Ghezel, Mahnaz Sandoughi, Zahra Heidari, Vahid Sheikhi, Mahmoud Ali Kaykhaei |
---|---|
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Adult Male endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism media_common.quotation_subject Population 030209 endocrinology & metabolism Newly diagnosed Gastroenterology Hyperthyroidism 03 medical and health sciences 0302 clinical medicine Endocrinology Hypothyroidism Internal medicine medicine Humans Euthyroid In patient education Molecular Biology Apolipoproteins A media_common education.field_of_study business.industry Thyroid disease Apolipoprotein AIV Appetite General Medicine Middle Aged medicine.disease 030104 developmental biology Case-Control Studies Female business hormones hormone substitutes and hormone antagonists Chylomicron Preliminary Data |
Zdroj: | Hormone molecular biology and clinical investigationReferences. 42(2) |
ISSN: | 1868-1891 |
Popis: | Objectives Apolipoprotein AIV has a role in chylomicrons and lipid secretion and catabolism. Also, Apo-AIV plays a role in the regulation of appetite and satiety. Previous studies on rats have shown that hyperthyroidism and hypothyroidism are associated with significant changes in Apo-AIV serum levels. There has been no research on serum Apo-AIV changes in hyper and hypothyroidism in humans. Methods This case-control study was performed on new patients with hyper and hypothyroidism. Eighteen patients with hyperthyroidism and 18 patients with hypothyroidism enrolled in the study. After 12 weeks treatment blood samples were recruited. If euthyroidism was achieved, serum Apo-AIV level was measured. Eighteen euthyroid healthy individuals without thyroid disease were chosen as the control group from general population. Results Serum levels of Apo-AIV before treatment in hypothyroidism, hyperthyroidism and in the control group were 85.61, 110.66 and 33.51 mg/dL respectively (p Conclusions The results of this study for the first time showed that the serum level of Apo-AIV is increased in patients with hyperthyroidism and is decreased in patients with hypothyroidism, and after treatment, there was a significant difference with the control group. |
Databáze: | OpenAIRE |
Externí odkaz: |