Thrombogenicity of Various Endovascular Stent Types: An In Vitro Evaluation
| Autor: | Sascha Khorchidi, Jakub Wiskirchen, Claus D. Claussen, Gunnar Tepe, Benjamin Pusich, Jörg Schmehl, Stephan H. Duda, Hans Peter Wendel |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Nitinol stent medicine.medical_specialty Surface Properties medicine.medical_treatment Antithrombin III Thrombogenicity In Vitro Techniques In vitro model Restenosis Alloys medicine Humans Radiology Nuclear Medicine and imaging Platelet activation Palmaz schatz stent Platelet Count business.industry Stent Thrombosis Platelet Activation Stainless Steel beta-Thromboglobulin medicine.disease Surgery Blood circulation Microscopy Electron Scanning Stents Cardiology and Cardiovascular Medicine business Nuclear medicine Peptide Hydrolases |
| Zdroj: | Journal of Vascular and Interventional Radiology. 13:1029-1035 |
| ISSN: | 1051-0443 |
| DOI: | 10.1016/s1051-0443(07)61868-5 |
| Popis: | The aim of this study was to evaluate the thrombogenicity of different peripheral stent types in a standardized in vitro model with fresh human whole blood.Different stents (N = 77; n = 7 of each of 11 types) were implanted in polyvinyl chloride tubing loops and filled with donor blood samples. After 120 minutes of blood circulation, the thrombin-antithrombin III complex (TAT) levels, beta-thromboglobulin (beta-TG) levels, and platelet counts were assessed.After 2 hours, significant differences were seen. TAT values (+/- SD) with the investigated stents were 31 micro g/mL +/- 20 (control, no stent), 328 micro g/mL +/- 206 (Saxx stent, peripheral medium CrNi31 L), 651 micro g/mL +/- 760 (Palmaz Corinthian Stent, 316 L stainless steel, electropolished), 1,609 micro g/mL +/- 1,264 (Palmaz Corinthian Stent, 316 L stainless steel, not electropolished), 810 micro g/mL +/- 578 (Palmaz Schatz long medium stent), 569 micro g/mL +/- 347 (Smart Nitinol stent), 1,037 micro g/mL +/- 577 (Megalink peripheral stent), 543 micro g/mL +/- 487 (peripheral stent, electropolished), 1,674 micro g/mL +/- 2,057 (peripheral stent, not electropolished), 3,128 micro g/mL +/- 1,812 (SelfX Nitinol stent, polished), 5,897 micro g/mL +/- 2,380 (SelfX Nitinol stent, unpolished), and 1,458 micro g/mL +/- 887 (bridge stent). The platelet count (x1,000/ micro L +/- SD) was 218 +/- 35 (control, no stent), 188 +/- 22 (Saxx stent), 187 +/- 20 (Palmaz Corinthian stent, electropolished), 135 +/- 37 (Palmaz Corinthian stent, not electropolished), 170 +/- 24 (Palmaz Schatz stent), 180 +/- 36 (Smart Nitinol stent), 159 +/- 26 (Megalink peripheral stent), 173 +/- 17 (peripheral stent, electropolished), 133 +/- 51 (peripheral stent, not electropolished), 123 +/- 37 (SelfX Nitinol stent, polished), 52 +/- 27 (SelfX Nitinol stent, unpolished), and 130 +/- 31 (bridge stent).This standardized study showed a wide range of platelet activation after stent implantation. Electropolishing clearly reduced the thrombogenicity of the stents. |
| Databáze: | OpenAIRE |
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