Platelet activation and myocardial necrosis in patients undergoing radiofrequency and cryoablation of isthmus-dependent atrial flutter
| Autor: | Reinhold Weber, Daniel Schlittenhardt, Thomas Arentz, Jochem Stockinger, Franz-Josef Neumann, Dietrich Kalusche, Dietmar Trenk, Gerd Bürkle, Willibald Hochholzer |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Platelet Membrane Glycoprotein IIb medicine.medical_specialty Platelet Function Tests Radiofrequency ablation medicine.medical_treatment Cryosurgery Statistics Nonparametric law.invention Necrosis Troponin T law Physiology (medical) Internal medicine medicine Humans Myocardial infarction Platelet activation Aspirin Chi-Square Distribution business.industry Anticoagulants Cryoablation Middle Aged medicine.disease Ablation Flow Cytometry Platelet Activation P-Selectin Treatment Outcome Atrial Flutter Cardiology Catheter Ablation Female Cardiology and Cardiovascular Medicine business Atrial flutter Biomarkers medicine.drug |
| Zdroj: | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 9(7) |
| ISSN: | 1099-5129 |
| Popis: | Aims Lower platelet activation by cryoenergy compared with radiofrequency (RF) energy was recently demonstrated immediately following ablation procedures of cardiac arrhythmias. Due to the delayed occurrence of cryolesions it is currently unknown, if cryoenergy and RF energy are associated with similar platelet activation and myocardial necrosis in the days after the procedure. Methods and results We enrolled 38 patients with common atrial flutter undergoing cavotricuspid isthmus ablation with either RF energy (n ¼ 23) or cryoenergy (n ¼ 13). Ten patients undergoing RF ablation and receiving aspirin served as antiplatelet control group. Troponin T and platelet surface protein expression of P-selectin were determined before and immediately after ablation as well as on day 1 and 2 thereafter. Rise in troponin T was amplified after RF ablation (0.50 + 0.37 mg/L) when compared with cryoablation (0.24 + 0.20 mg/L; P ¼ 0.024). In patients without aspirin, a significant increase in P-selectin expression was observed on day 1 after intervention in RF ablation compared with cryoablation (80 + 26 vs. 63 + 16 arbitrary units; P ¼ 0.048). Platelet activation was attenuated in patients receiving aspirin. Conclusion Successful ablation of atrial flutter with cryoenergy is associated with less myocardial necrosis and platelet activation compared with ablation with RF energy. Increased platelet activation following RF ablation can be attenuated by concomitant treatment with aspirin. |
| Databáze: | OpenAIRE |
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