Variability in C-reactive protein is associated with cognitive impairment in women living with and without HIV: a longitudinal study

Autor: Leah H. Rubin, Kathleen M. Weber, K. Anastos, Mary Young, Krithika N. Kumanan, Pauline M. Maki, Antonia Savarese, Philip J. Norris, Sheila M. Keating, Jane K. Burke-Miller, Gayle Springer, Saria Awadalla, Joel Milam, Lorie Benning, Victor Valcour
Rok vydání: 2017
Předmět:
0301 basic medicine
Oncology
Longitudinal study
Neurology
AIDS Dementia Complex
Type I
Neuropsychological Tests
Executive Function
Cognition
0302 clinical medicine
Receptors
Attention
Longitudinal Studies
Psychomotor learning
biology
Neuropsychology
Interleukin
virus diseases
Middle Aged
Mental Health
Infectious Diseases
C-Reactive Protein
Memory
Short-Term
Matrix Metalloproteinase 9
Medical Microbiology
Receptors
Tumor Necrosis Factor
Type I
HIV/AIDS
Female
medicine.symptom
CRP
Infection
Psychology
Adult
medicine.medical_specialty
Clinical Trials and Supportive Activities
Clinical Sciences
Inflammation
Article
03 medical and health sciences
Cellular and Molecular Neuroscience
Immune system
Memory
Clinical Research
Virology
Internal medicine
Behavioral and Social Science
medicine
Humans
Women
Aged
Interleukin-6
C-reactive protein
Neurosciences
HIV
030104 developmental biology
Short-Term
Case-Control Studies
Immunology
biology.protein
HIV-1
Neurology (clinical)
Tumor Necrosis Factor
030217 neurology & neurosurgery
Biomarkers
Psychomotor Performance
Zdroj: Journal of neurovirology, vol 24, iss 1
ISSN: 1538-2443
Popis: Despite the availability of effective antiretroviral therapies, cognitive impairment (CI) remains prevalent in HIV-infected (HIV+) individuals. Evidence from primarily cross-sectional studies, in predominantly male samples, implicates monocyte- and macrophage-driven inflammatory processes linked to HIV-associated CI. Thus, peripheral systemic inflammatory markers may be clinically useful biomarkers in tracking HIV-associated CI. Given sex differences in immune function, we focused here on whether mean and intra-individual variability in inflammatory marker-predicted CI in HIV+ and HIV- women. Seventy-two HIV+ (36 with CI) and 58 HIV- (29 with CI) propensity-matched women participating in the Women's Interagency HIV Study completed a neuropsychological battery once between 2009 and 2011, and performance was used to determine CI status. Analysis of 13 peripheral immune markers was conducted on stored biospecimens at three time points (7 and 3.5years before neuropsychological data collection and concurrent with data collection). HIV+ women showed alterations in 8 immune markers compared to HIV- women. The strongest predictors of CI across HIV+ and HIV- women were lower mean soluble tumor necrosis factor receptor I (sTNFRI) levels, higher mean interleukin (IL)-6 levels, and greater variability in C-reactive protein (CRP) and matrix metalloproteinase (MMP)-9 (p values
Databáze: OpenAIRE
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