Brain borders at the central stage of neuroimmunology

Autor: Justin Rustenhoven, Jonathan Kipnis
Rok vydání: 2022
Předmět:
Zdroj: Nature
ISSN: 1476-4687
0028-0836
Popis: The classical dogma suggested a disconnect between the immune and nervous systems, referred to as central nervous system immune privilege. However, recent studies have illuminated elegant workarounds at the borders of the central nervous system—putting these at the central stage of neuroimmune interactions. Despite the shared common goal to maintain homeostasis, under rare circumstances, immune and nervous systems may develop pathological interactions leading to neurological or psychiatric diseases. Here we discuss the recent findings that dissect the key anatomical, cellular, and molecular mechanisms that permit neuro-immune responses at the borders of the brain and spinal cord and the implications of these interactions for central nervous system diseases.
Databáze: OpenAIRE
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