Novel thiazolidine-2,4-diones as potent euglycemic agents
| Autor: | David Alan Clark, James P. Rizzi, W. H. Kappeler, Bernard Hulin, Paul J. Dambek, Ruth E. McDermott, Diana M. Lewis, Steven W. Goldstein, C. H. Lamphere |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Blood Glucose
chemistry.chemical_classification Ketone Stereochemistry Thiazolidine Ether Alcohol Biological activity Ketones Englitazone Mice Inbred C57BL Mice Thiazoles chemistry.chemical_compound Diabetes Mellitus Type 2 chemistry Alcohols Drug Discovery Animals Hypoglycemic Agents Molecular Medicine Moiety Benzopyrans Thiazolidinediones Oxazole |
| Zdroj: | Journal of Medicinal Chemistry. 35:1853-1864 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm00088a022 |
| Popis: | A new series of thiazolidine-2,4-diones was obtained by replacing the ether function of englitazone with various functional groups, i.e., a ketone, alcohol, or olefin moiety. These compounds lower blood glucose levels in the genetically obese and insulin-resistant ob/ob mouse. Appending an oxazole-based group at the terminus of the chain provided highly potent compounds. |
| Databáze: | OpenAIRE |
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