Assessment of toxicities and outcomes in patients with breast cancer treated with hypofractionated radiotherapy
| Autor: | Deepthi Valiyaveettil, Monica Malik, M Sindhu, Syed Fayaz Ahmed |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Hypofractionated Radiotherapy
Adult medicine.medical_specialty Nodal irradiation Breast pain Breast Neoplasms Young Adult Breast cancer Fibrosis Edema medicine Humans In patient Prospective Studies Prospective cohort study Radiation Injuries Aged Retrospective Studies Aged 80 and over business.industry Middle Aged medicine.disease Prognosis Survival Rate Oncology Female Radiation Dose Hypofractionation Radiotherapy Adjuvant Radiology medicine.symptom business Follow-Up Studies |
| Zdroj: | Indian journal of cancer. 57(4) |
| ISSN: | 1998-4774 |
| Popis: | Background: Hypofractionation is now becoming the standard of care in breast irradiation. The aim of this study was to assess the toxicities and outcomes in patients with breast cancer treated with hypofractionated radiotherapy (HFRT). Methods: Patients with localized breast cancer who received adjuvant HFRT between 2013 and 2015 with a minimum follow-up of 6 months following radiation were included in this prospective study. Late toxicities were assessed using CTCAE v 4 and included chest/breast pain, limb pain, limb edema, skin pigmentation, skin fibrosis, and shoulder movement restriction. Outcomes assessed included locoregional control, disease-free survival, and overall survival. Statistical analysis was done using Microsoft Excel and SPSS v22. Results: A total of 81 patients fulfilled the inclusion criteria, of which 19 patients had died during follow-up. Regional nodal irradiation was done in 63 (77.8%) patients using the same hypofractionated schedule of 40 Gy in 15 fractions. Late toxicities were assessed for 62 patients. The median follow-up following the course of hypofractionated radiation was 45 months (range 14 - 65 months). Late toxicities were assessed for 62 patients. Grade 1/2 chest/breast pain, limb pain, limb edema, skin pigmentation, skin fibrosis, and shoulder movement restriction were seen in 11%, 12%, 7%, 6%, 8%, and 11% of cases, respectively. Distant recurrences were seen in 8% of cases, and there were no locoregional recurrences. Five-year overall survival was 76.5%. Conclusion: HFRT to whole breast or chest wall and the regional nodal areas was well-tolerated with acceptable rates of late toxicities on follow-up. |
| Databáze: | OpenAIRE |
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