The midgut microbiota plays an essential role in sand fly vector competence forLeishmania major
| Autor: | Margery G. Smelkinson, Carolina Cunha Monteiro, Michael D. Lewis, David B. Sacks, Richard M. Merkhofer, Andrea Paun, Ludek Zurek, Ehud Inbar, Nágila Francinete Costa Secundino, Kashinath Ghosh, Phillip G. Lawyer, Dinesh Erram, Isabelle Louradour |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Sucrose medicine.drug_class 030231 tropical medicine Immunology Antibiotics Biology Microbiology Article 03 medical and health sciences 0302 clinical medicine Osmotic Pressure Virology medicine Animals Parasite hosting Colonization Leishmania major Pathogen Microbiota fungi Midgut medicine.disease biology.organism_classification Insect Vectors 030104 developmental biology Phlebotomus Psychodidae Dysbiosis Bacteria |
| Zdroj: | Cellular Microbiology. 19:e12755 |
| ISSN: | 1462-5814 |
| DOI: | 10.1111/cmi.12755 |
| Popis: | For many arthropod vectors, the diverse bacteria and fungi that inhabit the gut can negatively impact pathogen colonization. Our attempts to exploit antibiotic treatment of colonized Phlebotomus duboscqi sand flies in order to improve their vector competency for Leishmania major resulted instead in flies that were refractory to the development of transmissible infections due to the inability of the parasite to survive and to colonize the anterior midgut with infective, metacyclic stage promastigotes. The parasite survival and development defect could be overcome by feeding the flies on different symbiont bacteria but not by feeding them on bacterial supernatants or replete medium. The inhibitory effect of the dysbiosis was moderated by lowering the concentration of sucrose ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|