Three atypical lethal cases associated with acute Zika virus infection in Suriname
| Autor: | Jan Wilschut, Stephen Vreden, John Codrington, Rens Zonneveld, Jan Willem van Staveren, Jimmy Roosblad |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pediatrics medicine.medical_specialty DENGUE Case Report Disease Infectious and parasitic diseases RC109-216 Dengue fever Zika virus Sepsis 03 medical and health sciences MALARIA Zika EPIDEMIC medicine Coagulopathy AMERICA Hemorrhagic fever ZIKV biology Septic shock business.industry RT-PCR ASSAY medicine.disease biology.organism_classification Rash Leptospirosis Virology 030104 developmental biology Infectious Diseases CHIKUNGUNYA VIRUSES medicine.symptom business LEPTOSPIROSIS |
| Zdroj: | IDCases, Vol 5, Iss C, Pp 49-53 (2016) Idcases, 5, 49-53. ELSEVIER SCI LTD IDCases |
| ISSN: | 2214-2509 |
| Popis: | Acute Zika virus infection usually presents with a self-limiting triad of fever, rash and arthritis. There is limited information on severe or lethal cases. We report three cases of lethal acute Zika infection, confirmed with polymerase chain reaction, in adult patients with some co-morbidities. The patients showed rapid clinical deterioration with hemorrhagic and septic shock, and exaggerated acute and innate inflammatory responses with pronounced coagulopathy, and died soon after admission to the hospital. It remains unclear whether the fatal outcomes were due to acute Zika virus infection alone or to the combination with exacerbated underlying prior disease or co-infection. Nonetheless, the severity of these cases implies that increased awareness for atypical presentations of Zika virus infection, and careful clinical assessment of patients with symptoms of Zika, is warranted during current and future outbreaks. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license. |
| Databáze: | OpenAIRE |
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