Protective effect of a polyherbal bioactive fraction in propylthiouracil-induced thyroid toxicity in ratsby modulation of the hypothalamic–pituitary–thyroid and hypothalamic–pituitary–adrenal axes

Autor: S Sudhamani, Vandana S. Panda, Sneha Singh, Payal Dande
Jazyk: angličtina
Rok vydání: 2020
Předmět:
endocrine system diseases
Thyroid hormones
Health
Toxicology and Mutagenesis
medicine.medical_treatment
010501 environmental sciences
Toxicology
01 natural sciences
T3
Triiodothyronine
SOD
Superoxide dismutase
chemistry.chemical_compound
NIS
Sodium-iodide symporter
0302 clinical medicine
Hyperlipidemia
Medicine
HDL
High-density lipoprotein
GR
Glutathione reductase
Hcy
Homocysteine
CAT
Catalase
GA- Gallic acid
T1000
Tea-extract 1000 mg/kg
Polyherbal
Thyroid
TAE
T1000 mg/kg + Aerobic exercise
Regular Article
TG
Triglycerides
Malondialdehyde
HOMA
IR- Homeostatic model of insulin resistance
AE
Aerobic exercise
medicine.anatomical_structure
GPx
Glutathione peroxidase
HPTLC
High-performance thin layer chromatography
medicine.drug
IR
Insulin resistance
endocrine system
medicine.medical_specialty
Ru
Rutin
T1500
Tea-extract 1500 mg/kg
Levothyroxine
AC
Abdominal circumference
GSH
Reduced glutathione
03 medical and health sciences
Hypothyroidism
lcsh:RA1190-1270
LPO
Lipid peroxidation
Internal medicine
T500
Tea-extract 500 mg/kg
T4
thyroxine
Aerobic exercise
VLDL
Very low-density lipoprotein
MDA
Malondialedhyde
lcsh:Toxicology. Poisons
0105 earth and related environmental sciences
ComputingMethodologies_COMPUTERGRAPHICS
business.industry
Insulin
PTU
Propylthiouracil
medicine.disease
TC
total cholesterol
Endocrinology
chemistry
TSH
Thyroid stimulating hormone
Propylthiouracil
Uric acid
LDL
Low-density lipoprotein
business
030217 neurology & neurosurgery
Zdroj: Toxicology Reports
Toxicology Reports, Vol 7, Iss, Pp 730-742 (2020)
ISSN: 2214-7500
Popis: Graphical abstract
Highlights • Hypothyroidism is the most frequent toxic effect of a large variety of chemical compounds. • The polyherbal bioactive fraction exhibited a pro-thyroid effect in hypothyroidic rats. • The polyherbal fraction restored the propylthiouracil-depleted thyroid hormone levels significantly. • The polyherbal fraction may act through multiple mechanisms to exhibit a pro-thyroid effect.
Hypothyroidism is the most frequent consequence of the interaction of a large variety of drugs, environmental pollutants and industrial chemicals with the thyroid gland. It is associated with diminished endocrine function which may lead to hyperlipidemia, diabetes, Alzheimer’s disease, weight gain, and other metabolic disorders. The present study evaluates the pro-thyroid activity of a bioactive fraction from a polyherbal teabag in rats with hypothyroidism induced by propylthiouracil. The teabag was formulated to stimulate synthesis and/or release of T4 and affectthe conversion of T4 to T3. Phytoconstituents of the polyherbal teabag are potent antioxidants that may be responsible for the pro-thyroid activity. The tea-extract (1000 mg) was found to contain 1076 μg of gallic acid and 1131 μg of rutin from HPTLC analysis. Rats received propylthiouracil (8 mg/kg) for the first 15days followed by the polyherbal tea-extract (500, 1000 and 1500 mg/kg), the standard drug levothyroxine (0.1 mg/kg), aerobic exercise, and a combination of tea-extract (1000 mg/kg) and aerobic exercise daily along with propylthiouracil for the next 30 days. Finally, rats received their respective treatments alone without propylthiouracil for 15 more days. Lipid profile and levels of glucose, insulin, T3, T4, TSH, cortisol, homocysteine, creatinine, uric acid, malondialdehyde, glucose-6 phosphatase, and endogenous antioxidants were determined. All treatments attenuated significantly the propylthiouracil-elevated TSH, homocysteine, creatinine, uric acid, glucose-6-phosphatase, insulin, and malondialdehyde levels, and restored favorably the propylthiouracil-altered lipid profile, T3, T4, and endogenous antioxidant levels. The polyherbal tea-extract (1000 and 1500 mg/kg) treatment and thecombination treatment of tea-extract (1000 mg/kg) with aerobic exercise displayed significant restoration of the suboptimalthyroid function. This may be due to a favorablemodulation ofthe hypothalamic-pituitary–thyroid and the hypothalamic–pituitary–adrenal axes.
Databáze: OpenAIRE
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