S1PR1 and VEGFR2 – a synergy that promotes tumor angiogenesis?

Autor:	Zahid Akhter, Vigneshwaran Vellingiri, Dolly Mehta, Vijay Avin Balaji Ragunathrao, Mumtaz Anwar
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0301 basic medicine Tumor angiogenesis cAbl1 Cancer Research VEGF receptors Tumor vascularization 03 medical and health sciences 0302 clinical medicine Medicine S1PR1 biology business.industry Antagonist tumor angiogenesis respiratory system Endothelial stem cell 030104 developmental biology VEGFR2 030220 oncology & carcinogenesis Cancer research biology.protein cardiovascular system Commentary Molecular Medicine business circulatory and respiratory physiology Article Commentary
Zdroj:	Molecular & Cellular Oncology article-version (VoR) Version of Record
ISSN:	2372-3556
Popis:	We have recently uncovered that endothelial cell (EC) S1PR1 controls the effectiveness of VEGFR2 driven tumor angiogenesis. By using tumor ECs, EC-S1PR1−/- mice and S1PR1 antagonist, we showed that VEGF-VEGFR2 pathway requires EC-S1PR1-induced signaling to efficiently drive tumor vascularization and growth, indicating combining S1PR1 antagonist with anti-VEGF/VEGFR2 therapy may eradicate resistant tumors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589f9b87915388eaaf182e9cf186d6c4 http://europepmc.org/articles/PMC7469464 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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