Intake of Dietary Fruit, Vegetables, and Fiber and Risk of Colorectal Cancer According to Molecular Subtypes: A Pooled Analysis of 9 Studies
| Autor: | Marc J. Gunter, Yi Lin, Andrew T. Chan, Caroline Y. Um, Tabitha A. Harrison, Martha L. Slattery, Patrick S. Parfrey, Richard Barfield, Mingyang Song, Polly A. Newcomb, Efrat L. Amitay, Amanda I. Phipps, Robert S. Steinfelder, Wei Sun, Bethany Van Guelpen, Akihisa Hidaka, Steven Gallinger, Amanda E. Toland, Sonja I. Berndt, Marios Giannakis, Shuji Ogino, Sophia Harlid, Victor Moreno, Ulrike Peters, Heather Hampel, Xiaoliang Wang, Michael O. Woods, Mark A. Jenkins, Syed H.E. Zaidi, Jane C. Figueiredo, Daniel D. Buchanan, Mark A. Guinter, Reiko Nishihara, John D. Potter, Michael Hoffmeister, Stephen N. Thibodeau, Ivan Borozan, Lori C. Sakoda, Mireia Obón-Santacana, Li Hsu, Peter T. Campbell, Yin Cao |
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| Rok vydání: | 2020 |
| Předmět: |
Dietary Fiber
Male Proto-Oncogene Proteins B-raf 0301 basic medicine Oncology Cancer Research medicine.medical_specialty Colorectal cancer Biology medicine.disease_cause Logistic regression Article Proto-Oncogene Proteins p21(ras) 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Vegetables medicine Humans neoplasms 2. Zero hunger Case-control study Microsatellite instability Odds ratio DNA Methylation medicine.disease digestive system diseases 3. Good health 030104 developmental biology Quartile Case-Control Studies Fruit 030220 oncology & carcinogenesis CpG Islands Female Microsatellite Instability KRAS Colorectal Neoplasms Cohort study |
| Zdroj: | Cancer Res |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/0008-5472.can-20-0168 |
| Popis: | Protective associations of fruits, vegetables, and fiber intake with colorectal cancer risk have been shown in many, but not all epidemiologic studies. One possible reason for study heterogeneity is that dietary factors may have distinct effects by colorectal cancer molecular subtypes. Here, we investigate the association of fruit, vegetables, and fiber intake with four well-established colorectal cancer molecular subtypes separately and in combination. Nine observational studies including 9,592 cases with molecular subtypes for microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and somatic mutations in BRAF and KRAS genes, and 7,869 controls were analyzed. Both case-only logistic regression analyses and polytomous logistic regression analyses (with one control set and multiple case groups) were used. Higher fruit intake was associated with a trend toward decreased risk of BRAF-mutated tumors [OR 4th vs. 1st quartile = 0.82 (95% confidence interval, 0.65–1.04)] but not BRAF-wildtype tumors [1.09 (0.97–1.22); P difference as shown in case-only analysis = 0.02]. This difference was observed in case–control studies and not in cohort studies. Compared with controls, higher fiber intake showed negative association with colorectal cancer risk for cases with microsatellite stable/MSI-low, CIMP-negative, BRAF-wildtype, and KRAS-wildtype tumors (Ptrend range from 0.03 to 3.4e-03), which is consistent with the traditional adenoma-colorectal cancer pathway. These negative associations were stronger compared with MSI-high, CIMP-positive, BRAF-mutated, or KRAS-mutated tumors, but the differences were not statistically significant. These inverse associations for fruit and fiber intake may explain, in part, inconsistent findings between fruit or fiber intake and colorectal cancer risk that have previously been reported. Significance: These analyses by colorectal cancer molecular subtypes potentially explain the inconsistent findings between dietary fruit or fiber intake and overall colorectal cancer risk that have previously been reported. |
| Databáze: | OpenAIRE |
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