Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs
| Autor: | Monique Parant, Louis Chedid, P Lefrancher, Edgar Lederer, Jean Choay, Francine Parant |
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| Rok vydání: | 1977 |
| Předmět: |
Klebsiella pneumoniae
Injections Subcutaneous Administration Oral Peptidoglycan Immunoadjuvant Microbiology Mice Structure-Activity Relationship chemistry.chemical_compound Adjuvants Immunologic Immunity Animals Multidisciplinary Innate immune system biology Acetylmuramyl-Alanyl-Isoglutamine Immunogenicity Glycopeptides biology.organism_classification Glycopeptide Klebsiella Infections chemistry Injections Intravenous Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences. 74:2089-2093 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.74.5.2089 |
| Popis: | N-Acetylmuramyl-L-alanyl-D-isoglutamine and four other synthetic adjuvants that are structural analogs of part of the mycobacterial peptidoglycan monomer are shown to enhance the nonspecific immunity of mice infected by Klebsiella pneumoniae. These compounds are active by various routes, including oral administration; they are also effective when administered after challenge. Of the seventeen other analogs tested, none is able to increase significantly resistance to infection, although seven of these molecules are adjuvant-active in saline. Previous results have shown that in contrast to lipopolysaccharides, these synthetic adjuvants are devoid of immunogenicity, mitogenicity, and toxicity in normal or adrenalectomized mice. |
| Databáze: | OpenAIRE |
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