Depletion of circulating IgM memory B cells predicts unfavourable outcome in COVID-19

Autor:	Paolo Giuffrida, Emanuela Boveri, Stefania Merli, Patrizia Morbini, Ivan Pellegrino, Alessandro Rascaroli, Gino Roberto Corazza, Ginevra Cambiè, Nicola Aronico, Cristina Picone, Fausto Baldanti, A. Pasini, Valentina Antoci, Laura Vanelli, Antonio Di Sabatino, Umberto Sabatini, Alessandro Vanoli, Marco Paulli, Luca Arcaini, Annamaria Tenore, Marco Vincenzo Lenti, Federica Borrelli de Andreis, Francesco Di Terlizzi, C. Ubezio, Federica Melazzini
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Adult Male 0301 basic medicine medicine.medical_specialty Immunopathogenesis Coronavirus disease 2019 (COVID-19) Adaptive immunity B-Lymphocyte Subsets COVID-19 Lymphocytes Infectious diseases Spleen Gastroenterology Lymphocyte Depletion Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Cumulative incidence Hospital Mortality Longitudinal Studies Lymphocyte Count Prospective Studies 030212 general & internal medicine Memory B cell Aged Aged 80 and over B-Lymphocytes Multidisciplinary SARS-CoV-2 business.industry Impaired immune responses Mean age Middle Aged Northern italy 030104 developmental biology medicine.anatomical_structure Immunoglobulin M Peripheral blood lymphocyte Female business Immunologic Memory
Zdroj:	Scientific Reports Scientific reports, 10:20836
ISSN:	2045-2322
DOI:	10.1038/s41598-020-77945-8
Popis:	Impaired immune responses have been hypothesised to be a possible trigger of unfavourable outcomes in coronavirus disease 2019 (COVID-19). We aimed to characterise IgM memory B cells in patients with COVID-19 admitted to an internal medicine ward in Northern Italy. Overall, 66 COVID-19 patients (mean age 74 ± 16.6 years; 29 females) were enrolled. Three patients (4.5%; 1 female) had been splenectomised and were excluded from further analyses. Fifty-five patients (87.3%) had IgM memory B cell depletion, and 18 (28.6%) died during hospitalisation (cumulative incidence rate 9.26/100 person-week; 5.8–14.7 95% CI). All patients who died had IgM memory B cell depletion. A superimposed infection was found in 6 patients (9.5%), all of them having IgM memory B cell depletion (cumulative incidence rate 3.08/100 person-week; 1.3–6.8 95% CI). At bivariable analyses, older age, sex, number of comorbidities, and peripheral blood lymphocyte count
Databáze:	OpenAIRE
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