Children with optic nerve hypoplasia face a high risk of neurodevelopmental disorders

Autor: Sara Dahl, Ulla Ek, Kristina Teär Fahnehjelm, Ronny Wickström
Rok vydání: 2017
Předmět:
Male
Pediatrics
Neurology
Urban Population
genetic structures
Autism Spectrum Disorder
Neuropsychological Tests
Severity of Illness Index
0302 clinical medicine
Neurodevelopmental disorder
Optic Nerve Diseases
Intellectual disability
Prevalence
Child
Optic nerve hypoplasia
education.field_of_study
General Medicine
Prognosis
Child
Preschool
Female
medicine.symptom
Cohort study
medicine.medical_specialty
Adolescent
Visual impairment
Population
Risk Assessment
Young Adult
03 medical and health sciences
Age Distribution
Intellectual Disability
030225 pediatrics
medicine
Humans
Sex Distribution
education
Retrospective Studies
Sweden
business.industry
Infant
Newborn
Infant
medicine.disease
eye diseases
Cross-Sectional Studies
Neurodevelopmental Disorders
Pediatrics
Perinatology and Child Health
030221 ophthalmology & optometry
Autism
sense organs
business
Zdroj: Acta Paediatrica. 107:484-489
ISSN: 0803-5253
Popis: AIM Optic nerve hypoplasia (ONH) is a congenital ocular malformation that has been associated with neurodevelopmental disorders, but the prevalence in unilateral disease and less severe visual impairment is unknown. We studied intellectual disability and autism spectrum disorders (ASDs) in patients with ONH. METHODS This was a population-based cross-sectional cohort study of 65 patients (33 female) with ONH below 20 years of age, living in Stockholm in December 2009, with data analysed in January 2016. Of these 35 were bilateral and 30 were unilateral. Neurodevelopmental disorders were diagnosed or confirmed by neurological assessments, the Five to Fifteen parent questionnaire and reviewing previous neuropsychological investigations or conducting neuropsychological tests. RESULTS Bilateral ONH patients had lower mean full scale intelligence quotient scores than unilateral patients (84.4 and 99.4, respectively, p = 0.049). We assessed intellectual disability in 55 eligible patients, and it was more common in patients with bilateral ONH (18 of 32, 56%) than unilateral ONH (two of 23, 9%, p < 0.001). ASDs were diagnosed in seven of 42 (17%) patients. CONCLUSION Children with bilateral ONH had a high risk of neurodevelopmental disorders, especially intellectual disability. The risk was lower in unilateral ONH, but the levels of neurodevelopmental disorders warrant screening of both groups.
Databáze: OpenAIRE
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