Dyspeptic symptoms and delayed gastric emptying of solids in patients with inactive Crohn’s disease
| Autor: | Lúcia Libanês Bessa Campelo Braga, Kamila Maria Oliveira Sales, Armênio Aguiar dos Santos, Ana Carolina Mello Nóbrega, Graciela J. Oliveira, Marcellus H.L.P. Souza, Luizde Almeida Ernesto de Almeida Troncon, Miguel Ângelo Nobre e Souza, Bruno Roberto da Silva Ferreira |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Vomiting ESTUDOS DE CASOS E CONTROLES Population Gastric emptying Disease Gastroenterology Crohn Crohn Disease Internal medicine Dyspeptic Medicine Humans Carbon Radioisotopes Dyspepsia lcsh:RC799-869 education Aged Breath test Crohn's disease education.field_of_study medicine.diagnostic_test business.industry Case-control study General Medicine Hepatology Middle Aged medicine.disease digestive system diseases Breath Tests Case-Control Studies Female lcsh:Diseases of the digestive system. Gastroenterology medicine.symptom Caprylates business Research Article |
| Zdroj: | BMC Gastroenterology, Vol 12, Iss 1, p 175 (2012) BMC Gastroenterology Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Background Patients with Crohn’s disease (CD) have been shown to present dyspeptic symptoms more frequently than the general population. Some of these symptoms could be related to motility disorders to some degree. Then, we propose to investigate whether gastric emptying of solids in patients with inactive CD is delayed and to determine the relationships between gastric emptying and dyspeptic symptoms in inactive CD. Methods Twenty-six patients with inactive Crohn’s disease, as defined by a Crohn’s Disease Activity Index (CDAI) < 150, underwent a gastric emptying test by breath test using 13C octanoic acid coupled to a solid meal and answered a validated questionnaire (The Porto Alegre Dyspeptic Symptoms Questionnaire) to assess dyspeptic symptoms. Patients with scores ≥ 6 were considered to have dyspepsia. The control group was composed by 19 age- and sex-matched healthy volunteers. Results Patients with CD had a significantly longer t 1/2 and t lag (p Conclusion Delayed gastric emptying in inactive Crohn’s disease patients seems to be associated with dyspeptic symptoms, particularly vomiting, even without any evidence of gastrointestinal obstruction. |
| Databáze: | OpenAIRE |
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