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Tolterodine tartrate is an antimuscarnic or anticholinergic agent, It works by blocking a chemical that causes contraction of the bladder, It helps to reduce leaking of urine. This medication belongs to the class of drug known as antispasmodic. Tamsulosin HCL approximately 70% of the alpha-1-receptors in human prostate are of the alpha-1A subtype blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate. The most commonly adopted methods for determination both drugs are HPLC (High Performance Liquid Chromatography), HPTLC (High Performance Thin Layer Chromatography) , RP-UPLC (Reverse Phase –Ultra Performance Liquid Chromatography) and UV-Visible Spectroscopy. This article provides critical review on the methodologies available for qualitative and quantitative determination of Tolterodine tartrate and tamsulosin HCL in bulk and Pharmaceutical dosage forms. Keywords: Antimuscarnic, Tolterodine Tartrate, Tamsulosin HCL, RP-HPLC, UV-Spectroscopy, HPTLC, RP-UPLC. |
