Peak trabecular bone microstructure predicts rate of estrogen-deficiency-induced bone loss in rats
| Autor: | X. Sherry Liu, Yihan Li, Rebecca Chung, Wei Ju Tseng, Hongbo Zhao, Chantal M.J. de Bakker |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Peak bone mass medicine.medical_specialty Histology Physiology medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Ovariectomy Osteoporosis 030209 endocrinology & metabolism Article Bone remodeling 03 medical and health sciences 0302 clinical medicine Trabecula Bone Density Internal medicine Medicine Animals Humans Reduction (orthopedic surgery) business.industry Estrogens X-Ray Microtomography medicine.disease Microstructure Rats Menopause Bone Diseases Metabolic 030104 developmental biology medicine.anatomical_structure Endocrinology Estrogen Cancellous Bone Female business |
| Zdroj: | Bone |
| ISSN: | 1873-2763 |
| Popis: | Postmenopausal osteoporosis affects a large number of women worldwide. Reduced estrogen levels during menopause lead to accelerated bone remodeling, resulting in low bone mass and increased fracture risk. Both peak bone mass and the rate of bone loss are important predictors of postmenopausal osteoporosis risk. However, whether peak bone mass and/or bone microstructure directly influence the rate of bone loss following menopause remains unclear. Our study aimed to establish the relationship between peak bone mass/microstructure and the rate of bone loss in response to estrogen deficiency following ovariectomy (OVX) surgery in rats of homogeneous background by tracking the skeletal changes using in vivo micro-computed tomography (μCT) and three-dimensional (3D) image registrations. Linear regression analyses demonstrated that the peak bone microstructure, but not peak bone mass, was highly predictive of the rate of OVX-induced bone loss. In particular, the baseline trabecular thickness was found to have the highest correlation with the degree of OVX-induced bone loss and trabecular stiffness reduction. Given the same bone mass, the rats with thicker baseline trabeculae had a lower rate of trabecular microstructure and stiffness deterioration after OVX. Moreover, further evaluation to track the changes within each individual trabecula via our novel individual trabecular dynamics (ITD) analysis suggested that a trabecular network with thicker trabeculae is less likely to disconnect or perforate in response to estrogen deficiency, resulting a lower degree of bone loss. Taken together, these findings indicate that the rate of estrogen-deficiency-induced bone loss could be predicted by peak bone microstructure, most notably the trabecular thickness. Given the same bone mass, a trabecular bone phenotype with thin trabeculae may be a risk factor toward accelerated postmenopausal bone loss. |
| Databáze: | OpenAIRE |
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