Early reduced behavioral activity induced by large strokes affects the efficiency of enriched environment in rats
| Autor: | Anna-Sophia Wahl, Julia Kaiser, Uta Büchler, Eva Erlebach, Stefan Imobersteg, Martin E. Schwab, Shirin Schneeberger, Martina Stirn, Benjamin V. Ineichen, Aileen Schroeter, Bjoern Ommer, Alice C Mosberger, Martin Wieckhorst, Biagio Brattoli |
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| Přispěvatelé: | University of Zurich, Wahl, Anna-Sophia |
| Rok vydání: | 2018 |
| Předmět: |
time windows
medicine.medical_treatment Physiology 610 Medicine & health Systemic inflammation 2705 Cardiology and Cardiovascular Medicine 03 medical and health sciences 0302 clinical medicine Immune system medicine Animals Rats Long-Evans Immune response Stroke Fatigue Neurorehabilitation Inflammation neurorehabilitation Environmental enrichment Neuronal Plasticity business.industry Stroke Rehabilitation Recovery of Function Original Articles Immunotherapy medicine.disease stroke Rats Clinical trial Disease Models Animal 2728 Neurology (clinical) Neurology 2808 Neurology Training intensity 11404 Department of Clinical Diagnostics and Services Female immunotherapy Neurology (clinical) medicine.symptom Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Cerebral Blood Flow & Metabolism J Cereb Blood Flow Metab |
| ISSN: | 0271-678X |
| DOI: | 10.1177/0271678X18777661 |
| Popis: | The majority of stroke patients develop post-stroke fatigue, a symptom which impairs motivation and diminishes the success of rehabilitative interventions. We show that large cortical strokes acutely reduce activity levels in rats for 1–2 weeks as a physiological response paralleled by signs of systemic inflammation. Rats were exposed early (1–2 weeks) or late (3–4 weeks after stroke) to an individually monitored enriched environment to stimulate self-controlled high-intensity sensorimotor training. A group of animals received Anti-Nogo antibodies for the first two weeks after stroke, a neuronal growth promoting immunotherapy already in clinical trials. Early exposure to the enriched environment resulted in poor outcome: Training intensity was correlated to enhanced systemic inflammation and functional impairment. In contrast, animals starting intense sensorimotor training two weeks after stroke preceded by the immunotherapy revealed better recovery with functional outcome positively correlated to the training intensity and the extent of re-innervation of the stroke denervated cervical hemi-cord. Our results suggest stroke-induced fatigue as a biological purposeful reaction of the organism during neuronal remodeling, enabling new circuit formation which will then be stabilized or pruned in the subsequent rehabilitative training phase. However, intense training too early may lead to wrong connections and is thus less effective. |
| Databáze: | OpenAIRE |
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