Central Injection of Ketone Body Suppresses Luteinizing Hormone Release via the Catecholaminergic Pathway in Female Rats
| Autor: | Kinuyo Iwata, Kei-ichiro Maeda, Naoki Susaki, Yoshihisa Uenoyama, Mika Kinoshita, Hiroko Tsukamura |
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| Rok vydání: | 2011 |
| Předmět: |
Blood Glucose
endocrine system medicine.medical_specialty medicine.drug_class Ketone Bodies chemistry.chemical_compound Catecholamines Corticosterone Internal medicine medicine Animals Rats Wistar Catecholaminergic Estrous cycle Fourth Ventricle 3-Hydroxybutyric Acid Luteinizing Hormone medicine.disease Rats alpha-Methyltyrosine Endocrinology chemistry Ketone bodies Ovariectomized rat Female Animal Science and Zoology Gonadotropin Ketosis Luteinizing hormone hormones hormone substitutes and hormone antagonists Paraventricular Hypothalamic Nucleus |
| Zdroj: | Journal of Reproduction and Development. 57:379-384 |
| ISSN: | 1348-4400 0916-8818 |
| DOI: | 10.1262/jrd.11-001s |
| Popis: | Ketosis is found in various pathophysiological conditions, including diabetes and starvation, that are accompanied by suppression of gonadal activity. The aim of the present study was to determine the role of ketone body in the brain in regulating pulsatile luteinizing hormone (LH) secretion in female rats. Injection of 3-hydroxybutyrate (3HB), a ketone body, into the fourth cerebroventricle (4V) induced suppression of pulsatile LH secretion in a dose-dependent manner in ovariectomized (OVX) rats with an estradiol (E2) implant producing diestrus plasma E2 levels. Plasma glucose and corticosterone levels increased immediately after the 4V 3HB injection, suggesting that the treatment caused a hunger response. The 3HB-induced suppression of LH pulses might be mediated by noradrenergic inputs to the hypothalamic paraventricular nucleus (PVN) because a local injection of α-methyl- p-tyrosine, a catecholamine synthesis inhibitor, into the PVN blocked 3HB-induced suppression of LH pulses and PVN noradrenaline release was increased by 4V 3HB injection in E2-primed OVX rats. These results suggest that ketone body sensed by a central energy sensor in the hindbrain may suppress gonadotropin release via noradrenergic inputs to the PVN under ketosis. |
| Databáze: | OpenAIRE |
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