Regulation of Muscle Microcirculation in Health and Diabetes
| Autor: | Zhenqi Liu, Wei Dong Chai, Seung Hyun Ko, Wen Hong Cao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Type 2 diabetes Review 030204 cardiovascular system & hematology lcsh:Diseases of the endocrine glands. Clinical endocrinology Microcirculation 03 medical and health sciences 0302 clinical medicine Insulin resistance Microvasculature Internal medicine Diabetes mellitus medicine Insulin Endothelium 030304 developmental biology 0303 health sciences lcsh:RC648-665 biology business.industry Vasorelaxation Nitric oxide medicine.disease Angiotensin II 3. Good health Insulin receptor Endocrinology Vasoconstriction biology.protein Muscle medicine.symptom business Muscle contraction |
| Zdroj: | Diabetes & Metabolism Journal Diabetes & Metabolism Journal, Vol 36, Iss 2, Pp 83-89 (2012) |
| ISSN: | 2233-6087 2233-6079 |
| Popis: | Insulin increases microvascular perfusion and substrate exchange surface area in muscle, which is pivotal for hormone action and substrate exchange, by activating insulin signaling cascade in the endothelial cells to produce nitric oxide. This action of insulin is closely coupled with its metabolic action and type 2 diabetes is associated with both metabolic and microvascular insulin resistance. Muscle microvascular perfusion/volume can be assessed by 1-methylxanthine metabolism, contrast-enhanced ultrasound and positron emission tomography. In addition to insulin, several factors have been shown to recruit muscle microvasculature, including exercise or muscle contraction, mixed meals, glucagon-like peptide 1 and angiotensin II type 1 receptor (AT(1)R) blocker. On the other hand, factors that cause metabolic insulin resistance, such as inflammatory cytokines, free fatty acids, and selective activation of the AT(1)R, are capable of causing microvascular insulin resistance. Therapies targeting microvascular insulin resistance may help prevent or control diabetes and decrease the associated cardiovascular morbidity and mortality. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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