Gingival Crevicular Fluid (GCF): A Diagnostic Tool for the Detection of Periodontal Health and Diseases
Autor: | Ambreen Rehman, Zohaib Khurshid, Tauqeer Fatima, Kumar Chandan Srivastava, Deepti Shrivastava, Eisha Imran |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Periodontal tissue Disease status gingival inflammation inflammatory mediators Pharmaceutical Science Review Disease Analytical Chemistry Crevicular fluid lcsh:QD241-441 03 medical and health sciences 0302 clinical medicine Periodontal disease lcsh:Organic chemistry Drug Discovery medicine Humans Physical and Theoretical Chemistry Intensive care medicine periodontitis Periodontal Diseases 030304 developmental biology Periodontitis 0303 health sciences business.industry Organic Chemistry biomarkers 030206 dentistry medicine.disease proteomes gingival crevicular fluid Chemistry (miscellaneous) Molecular Medicine Disease prevention business Clinical evaluation |
Zdroj: | Molecules, Vol 26, Iss 1208, p 1208 (2021) Molecules |
ISSN: | 1420-3049 |
Popis: | The methodologies applicable for the evaluation of periodontal associated diseases are constantly evolving to provide quick, realistic, and scientifically proven results. Trends in the past followed a clinical evaluation of periodontal tissues and radiographic-based reports that formed the foundation for detection of diseases involving the structures supporting the teeth. As the confines and limitations of conventional strategies became obvious over the passage of time, hand in hand variety of techniques have evolved and experimentally justified. These improvisations are based on an improved understanding of the periodontal-pathogenic cascade. Periodontal pathogenesis and a paradigm shift from disease understanding to disease prevention and treatment entail few prerequisites that demand the objectivity of diagnostics procedure that includes sensitivity and specificity along with an explanation of the intensity of the disease, Gingival crevicular fluid an oral bio-fluid resides in the close proximity with gingival tissues have been widely used to understand and differentiate the periodontal health and diseased status. The biomarkers present in the GCF can be a reliable tool to detect the minute changes seen in the disease processes. The GCF consists of various host and bacterial-derived products as well as biomarkers which in turn can be evaluated for the diagnosis, prognosis as well as management of the periodontal disease. Thus, the review aims at describing GCF as a potential oral biofluid helpful in differentiating periodontal health and disease status. |
Databáze: | OpenAIRE |
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