Screening data for the endocrine disrupting activities of 583 chemicals using the yeast two-hybrid assay
| Autor: | Yoshitaka Imaizumi, Fujio Shiraishi, Ryo Kamata, Masanori Terasaki, Mayuko Yagishita, Hidetaka Takigami, Daisuke Nakajima |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Multidisciplinary biology Chemistry Estrogen receptor binding Two-hybrid screening Estrogen receptor Japanese Medaka Aryl hydrocarbon receptor lcsh:Computer applications to medicine. Medical informatics Yeast Androgen receptor 03 medical and health sciences 030104 developmental biology Biochemistry Biochemistry Genetics and Molecular Biology biology.protein Endocrine system lcsh:R858-859.7 lcsh:Science (General) lcsh:Q1-390 |
| Zdroj: | Data in Brief, Vol 21, Iss, Pp 2543-2546 (2018) Data in Brief |
| ISSN: | 2352-3409 |
| Popis: | We screened 583 chemicals for receptor binding activity to the human estrogen receptor (hER), the Japanese medaka estrogen receptor (medER), and the aryl hydrocarbon receptor (AhR) using the yeast two-hybrid assay. The substances tested included substances that could potentially be produced unintentionally by industrial processes, such as halogenated steroids and phenols. Antagonistic effects on hER and the androgen receptor were also screened. The test chemicals were selected for screening on the basis of chemical structure associated with possible estrogen receptor binding activity. The current study presents the report on the screening of 583 chemicals for different kinds of endocrine disrupting activity. |
| Databáze: | OpenAIRE |
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