UNC-55, an Orphan Nuclear Hormone Receptor, Orchestrates Synaptic Specificity among Two Classes of Motor Neurons inCaenorhabditis elegans
| Autor: | W. W. Walthall, Zhou Hm |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Recombinant Fusion Proteins
Green Fluorescent Proteins Molecular Sequence Data Receptors Cytoplasmic and Nuclear Receptors Cell Surface Polymerase Chain Reaction Article biology.animal medicine Animals Humans Gene family Amino Acid Sequence Cloning Molecular Caenorhabditis elegans Caenorhabditis elegans Proteins Transcription factor Zebrafish Body Patterning Motor Neurons Base Sequence Sequence Homology Amino Acid biology General Neuroscience Vertebrate Sequence Analysis DNA Motor neuron biology.organism_classification Luminescent Proteins Ovalbumin medicine.anatomical_structure nervous system Nuclear receptor Multigene Family Synapses biology.protein Drosophila Sequence Alignment Neuroscience Function (biology) |
| Zdroj: | The Journal of Neuroscience. 18:10438-10444 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.18-24-10438.1998 |
| Popis: | Loss of UNC-55 function in the nematodeCaenorhabditis eleganscauses one motor neuron class, the ventral D (VD) motor neurons, to adopt the synaptic pattern of another motor neuron class, the dorsal D (DD) motor neurons. Here we show thatunc-55encodes a member of the nuclear hormone receptor gene family that is similar to the vertebrate chicken ovalbumin upstream promoter transcription factors. Although the VD and DD motor neuron classes arise from different lineages at different developmental stages, they share a number of structural and functional features that appear to be the product of identical genetic programs. UNC-55 is expressed in the VD but not the DD motor neurons to modify this genetic program and to create the synaptic pattern that distinguishes the two motor neuron classes from one another. |
| Databáze: | OpenAIRE |
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