Pharmacology of aztreonam after intravenous infusion
| Autor: | E A Swabb, H C Neu, B E Scully |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Male Time Factors Urine Aztreonam Pharmacology Excretion chemistry.chemical_compound Minimum inhibitory concentration Pharmacokinetics Humans Medicine Infusions Parenteral Pharmacology (medical) Volume of distribution Bacteria biology business.industry Liter biology.organism_classification Enterobacteriaceae Anti-Bacterial Agents Kinetics Infectious Diseases chemistry business Research Article |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 24:18-22 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.24.1.18 |
| Popis: | The pharmacokinetics of aztreonam, a monocyclic beta-lactam which inhibits most members of the family Enterobacteriaceae at concentrations of less than 1 microgram/ml and most Pseudomonas aeruginosa isolates at concentrations of less than 16 micrograms/ml, were examined in healthy male volunteers after 30-min intravenous infusions of 0.5, 1, and 2 g of the drug. Mean peak levels of the drug in serum at the end of infusion were 65.5, 164, 255 micrograms/ml after 0.5 1, and 2 g, respectively, with levels of the drug in serum of 1.8, 3, and 8.5 micrograms/ml at 8.5 h for the three doses, respectively. The half-life was approximately 2 h for all three doses. The total serum clearance averaged 1 ml/min per kg. The apparent volume of distribution averaged 0.17 liter/kg for the three doses. Overall excretion of the drug in urine was 61%, with mean levels in urine of 23, 52, and 109 micrograms/ml at 8.5 to 12.5 h after 0.5, 1, and 2 g of aztreonam, respectively. Concentrations of the drug in serum after a 1-g dose exceeded the minimal inhibitory concentration for 90% of the members of the Enterobacteriaceae by four- to eightfold for 8 h and exceeded the minimal inhibitory concentration for P. aeruginosa isolates for 4 h. |
| Databáze: | OpenAIRE |
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