Elucidating the role of hyposalivation and autoimmunity in oral candidiasis
| Autor: | Margaret Grisius, Ilias Alevizos, Bruce A. Dye, Timothy Iafolla, Monisha Billings |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Saliva medicine.medical_specialty Adolescent Population Autoimmunity Lower risk Xerostomia Gastroenterology Article Autoimmune Diseases Young Adult 03 medical and health sciences Sex Factors 0302 clinical medicine Candidiasis Oral Risk Factors Interquartile range Diabetes mellitus Internal medicine Diabetes Mellitus Prevalence Humans Medicine Child education General Dentistry Aged Aged 80 and over education.field_of_study business.industry Confounding Case-control study Middle Aged medicine.disease Sjogren's Syndrome 030104 developmental biology Otorhinolaryngology Case-Control Studies 030220 oncology & carcinogenesis Cohort Female business |
| Zdroj: | Oral Diseases. 23:387-394 |
| ISSN: | 1354-523X |
| DOI: | 10.1111/odi.12626 |
| Popis: | Introduction Oral candidiasis (OC) is a potential oral complication in Sjogren's syndrome (SS). Some studies indicate that the low stimulated salivary flow and not low unstimulated salivary flow is associated with OC in SS, while others report that the underlying autoimmune disorders contribute to OC, based solely on correlation coefficients. Given the conflicting and limited existing evidence, we purposed to ascertain the role of both salivary gland dysfunction (hyposalivation based on unstimulated and stimulated flow rates) and autoimmunity (SS, other autoimmune disorders) in OC among those with SS, other salivary gland dysfunction, and non-salivary gland dysfunction controls (NSGD). Methods A nested case–control study was designed within a larger NIH/NIDCR cohort. Descriptive analyses, nonparametric tests, comparative analyses, and multivariate logistic regression analyses were undertaken. Results Data on 1526 subjects (701 SS, 247 ISS, 355 Sicca, and 223 NSGD) were obtained from the source cohort of 2046 and analyzed for this study. The median whole unstimulated salivary flow rate (WUS, ml 15 min−1) was lower in SS (0.8, interquartile range (IQR) 1.8) compared to ISS (5.5, IQR: 5.2, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text