Study on the Mechanism of Fu Zi Li Zhong Decoction in Treating Gastric Ulcer and its Effect on Gastrointestinal Microecology
| Autor: | Zhu Meng-Chen, Huang Jia-Wang, Liao Can, Xie Xi, Chen Ping-An, Yuan Ping, Li Ling, Wang Jian |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
H&E stain Medicine (miscellaneous) lcsh:Medicine Health Informatics Decoction Occludin Gastroenterology Ranitidine Internal medicine Edema Medicine business.industry lcsh:R lcsh:Other systems of medicine lcsh:RZ201-999 Microecology digestive system diseases Computer Science Applications Complementary and alternative medicine Pharmacodynamics Histopathology medicine.symptom business human activities medicine.drug |
| Zdroj: | Digital Chinese Medicine, Vol 2, Iss 3, Pp 147-156 (2019) |
| ISSN: | 2589-3777 |
| Popis: | Objective: To explore the pharmacodynamic mechanism of Fu Zi Li Zhong Decoction (FZLZD) in treating gastric ulcer and its effect on gastrointestinal microecology. Methods: Rat gastric ulcer model was established by continuous vinegar gavage. The experiment included normal group, model group, ranitidine group and FZLZD group. The animals were handled after intragastricing administration of corresponding clinical isodose drugs for 7 d. The rats’ gastrointestinal histopathology was observed by HE staining. The expression of ZO-1 and Occludin mRNA in rat gastric tissue was detected by RT-PCR. The diversity of intestinal flora was analyzed by 16SrDNA sequencing. Results: FZLZD can effectively improve gastric mucosal destruction, epithelial exfoliation, inflammatory cell infiltration, inflammatory substance exudation and edema in rats with gastric ulcer. FZLZD can effectively up-regulate the expression levels of ZO-1 and Occludin mRNA in gastric tissue of rats with gastric ulcer. The results of intestinal flora diversity showed that the diversity of intestinal flora in FZLZD group was significantly higher than that of model group. Conclusions: FZLZD can regulate gastric ulcer by promoting the expression of ZO-1 and Occludin and improving the diversity of intestinal flora. Keywords: Fu Zi Li Zhong Decoction (FZLZD) Gastric ulcer, ZO-1, Occludin, Intestinal flora diversity, 16SrDNA |
| Databáze: | OpenAIRE |
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