Chromosomal study of enteric glial cells and neurons by fluorescence in situ hybridization in slow transit constipation
| Autor: | G Bassotti, P Grigolato, Vincenzo Villanacci, Simona Fisogni, A Morelli, E. Rossi, B Salerni |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology chromosomes Physiology Biopsy In situ hybridization enteric neurons Biology Gastroenterology Enteric Nervous System Pathogenesis FISH Internal medicine medicine Humans Slow transit constipation Gastrointestinal Transit In Situ Hybridization Fluorescence Aged Chromosome Aberrations Neurons medicine.diagnostic_test Endocrine and Autonomic Systems enteric glial cells slow transit constipation Chromosome Middle Aged Control subjects Fish Female Constipation Neuroglia Biomarkers Fluorescence in situ hybridization |
| Popis: | The pathogenesis of slow transit constipation is still elusive. However, a genetic basis may be present. We investigated possible chromosomal abnormalities in enteric neurons and glial cells in patients with slow transit constipation. Colonic specimens from 22 patients with slow transit constipation undergoing surgery for intractable symptoms were obtained, and investigated by fluorescence in situ hybridization (FISH) for chromosomal abnormalities (chromosomes 1, 8, 17 and XY). These specimens were compared with of those obtained in 12 control subjects. Data analysis showed that 45.5% of patients displayed significant (>10%) aneusomy of chromosome 1 in enteric neurons. Aneusomy |
| Databáze: | OpenAIRE |
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