Spontaneous brain tumor imaging of aged rat by crystal X-ray interferometer-based phase-contrast X-ray CT
| Autor: | Hiroko Maruyama, Tsubasa Matsushima, Kei Terazaki, Atsuko Hara, Tohoru Takeda, Shogo Esashi, Kazuyuki Hyodo, Masaya Taguchi, Akio Yoneyama, Thet-Thet Lwin, Makoto Ohbu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty Phase contrast microscopy media_common.quotation_subject Brain tumor Magnification Case Report computed tomography (CT) 030218 nuclear medicine & medical imaging law.invention 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance law medicine Contrast (vision) aged rat Pathological media_common Crystal X-ray interferometer-based phase-contrast X-ray CT (C-PCCT) spontaneous brain tumor business.industry X-ray General Medicine medicine.disease X-ray interferometer business 030217 neurology & neurosurgery Aged rat |
| Zdroj: | Acta Radiologica Open |
| ISSN: | 2058-4601 |
| DOI: | 10.1177/2058460115626958 |
| Popis: | Background Crystal X-ray interferometer-based phase-contrast X-ray computed tomography (C-PCCT) enables the depiction of internal structures of biological tissue without contrast agents. Purpose To determine the advantage of this technique in visualizing detailed morphological structures of a rare spontaneous brain tumor in an aged rat. Material and Methods An aged rat’s spontaneous brain tumor was imaged by C-PCCT without contrast agent. Three-dimensional (3D) images of the tumor microvasculature were reconstructed and compared with pathological pictures. Results C-PCCT depicted the tumor’s various pathological features clearly, e.g. its cell density and vasculature, and blood clots caused by hemorrhaging and/or hematomas. The obtained images resembled pathological pictures with a magnification of ×20 and were used to reconstruct 3D images of the tumor vascularity up to approximately 26 µm in diameter. Conclusion Since C-PCCT is able to depict various pathological conditions, it might be useful for cancer research. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|